Ziprasidone Hydrochloride is one of the drugs of choice for the Psychosis. It has a half life of 8 h. The present investigation is concerned with the development of the fast dissolving tablets. Fast dissolving tablets of Ziprasidone hydrochloride were prepared by sublimation method. Ziprasidone hydrochloride showed maximum absorption at wavelength 317 nm in phosphate buffer pH 7.4. Various formulations were developed by using different concentration of superdisintegrant and camphor. The prepared batches were evaluated for pharmacotechnical parameter like hardness, friability, weight variation, in vitro disintegration time, wetting time, water absorption ratio, in vitro drug release studies, and stability studies. Drug-polymer compatibility studies by FTIR gave conformation about drug purity and showed no interaction between drug and selected polymers. All the formulations exhibited in vitro disintegration time below 57 seconds. From among all the developed formulations Z9 containing Cropovidone-6mg, Camphor-15mg showed minimum time to disintegrate (37 sec.) and almost complete release of drug within 30 minutes. The best formulations were found to be stable during stability studies done for one month. Thus, best formulations satisfied physico-chemical parameters, friability, wetting time, in vitro disintegration time and in vitro drug release profile requirements for fast dissolving tablets. Tablets of Ziprasidone HCl prepared with Crospovidone and Camphor were found to be acceptable in vitro disintegration time, water uptake, friability and in vitro drug release. Finally it was concluded that FDT of Ziprasidone Hydrochloride can be successfully formulated by sublimation methods.
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